An iridium-catalyzed annulation between 1,2-diarylethanone and 3-aminopropanol was developed, leading to site specific 2,3-diarylpyridines in moderate yields. 3-Aminopropanol served as both a four-atom component and solvent during this procedure, releasing… Click to show full abstract
An iridium-catalyzed annulation between 1,2-diarylethanone and 3-aminopropanol was developed, leading to site specific 2,3-diarylpyridines in moderate yields. 3-Aminopropanol served as both a four-atom component and solvent during this procedure, releasing water as a clean by-product. The reaction may proceed with sequential imine formation, alcohol oxidation and intramolecular cyclization by Knoevenagel reaction.
Keywords:
annulation diarylethanone;
site specific;
iridium catalyzed;
diarylethanone aminopropanol;
catalyzed annulation
Journal Title: Tetrahedron Letters
Year Published: 2017
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Journal Title: Tetrahedron Letters
Year Published: 2017
Link to full text (if available)
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recommendations!