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Synthesis of d-glycero-d-manno-heptose 1,7-bisphosphate (HBP) featuring a β-stereoselective bis-phosphorylation

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Abstract d - glycero - d - manno -Heptose 1,7-bisphosphate (HBP) plays a unique role in bacteriology. We describe in this study a very efficient synthesis of HBP, featuring a… Click to show full abstract

Abstract d - glycero - d - manno -Heptose 1,7-bisphosphate (HBP) plays a unique role in bacteriology. We describe in this study a very efficient synthesis of HBP, featuring a highly 6-D-selective construction of the heptose scaffold as well as a double phosphorylation step installing, in a single operation and in a β-stereoselective manner, the 1- and the 7-phosphates.

Keywords: bisphosphate hbp; glycero manno; hbp featuring; hbp; heptose bisphosphate; manno heptose

Journal Title: Tetrahedron Letters
Year Published: 2017

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