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Abstract A highly efficient catalytic system, CuSO 4 ·5H 2 O/1-(4-methoxyphenyl)-3-phenylthiourea, for the copper(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) was discovered. In the above catalytic system, substituted thiourea acts both as… Click to show full abstract
Abstract A highly efficient catalytic system, CuSO 4 ·5H 2 O/1-(4-methoxyphenyl)-3-phenylthiourea, for the copper(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) was discovered. In the above catalytic system, substituted thiourea acts both as a reductant and a ligand. CuSO 4 ·5H 2 O/1-(4-methoxyphenyl)-3-phenylthiourea is both an economical and efficient catalyst for the CuAAC reaction. In addition, the new catalytic system has advantageous features including mild and green reaction conditions, and broad substrate compatibility. A variety of 1,4-disubstituted 1,2,3-triazoles have been prepared with good to excellent yields with the CuSO 4 ·5H 2 O/1-(4-methoxyphenyl)-3-phenylthiourea catalytic system in aqueous solution.
Journal Title: Tetrahedron Letters
Year Published: 2017
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