LAUSR

Abstract In contrast to the conventional deleterious approach for nitration (for example HNO 3 /H 2 SO 4 ) and for reduction (for example Zn/HCl), we hypothesized that sensitive heterocycles such as coumarins could not withstand with those hard conditions. Hence, while studying this reaction sequence to prepare amino coumarins (which is our ongoing project to synthesize antitubercular coumarin agents), we came across mild and greener reagent for nitration using calcium nitrate (Ca(NO 3 ) 2 ·4H 2 O; lime nitrate), and reduction using d -glucose. These two mild, chemoselective, high yielding methods are discussed herein.