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Preparation and reactivity of sterically encumbered organocatalysts and their use in the preparation of (S)-Pregabalin precursors

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Abstract Herein we describe the preparation of a new class of sterically demanding organocatalysts derived from d -fructose and their use, alongside hitherto unreported doubly quaternarised Cinchona ammonium salts, in… Click to show full abstract

Abstract Herein we describe the preparation of a new class of sterically demanding organocatalysts derived from d -fructose and their use, alongside hitherto unreported doubly quaternarised Cinchona ammonium salts, in the Michael reaction of nitromethane with 4-nitro-5-alkenyl-isoxazoles.

Keywords: reactivity sterically; preparation reactivity; sterically encumbered; encumbered organocatalysts; organocatalysts use; preparation

Journal Title: Tetrahedron Letters
Year Published: 2017

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