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Abstract A base-promoted formal [4 + 1+1] annulation of aldehyde, N-benzyl amidine and DMSO was developed, leading to a series of 2,4,6-triaryl pyrimidines in moderate to good yields. Notably, DMSO served as… Click to show full abstract
Abstract A base-promoted formal [4 + 1+1] annulation of aldehyde, N-benzyl amidine and DMSO was developed, leading to a series of 2,4,6-triaryl pyrimidines in moderate to good yields. Notably, DMSO served as a methine source, which was activated by base rather than either Lewis acid or electrophile. Molecular O2 was the sole eco-friendly oxidant during this procedure.
Keywords:
aldehyde benzyl;
promoted formal;
formal annulation;
benzyl amidine;
annulation aldehyde;
base promoted
Journal Title: Tetrahedron Letters
Year Published: 2017
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Journal Title: Tetrahedron Letters
Year Published: 2017
Link to full text (if available)
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recommendations!