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Abstract A K 3 PO 4 promoted dipolar [3+3] cyclization of dihydroisoquinoline imines and arylacyl bromides has been developed. This process realized the direct synthesis of pyrazino[2,1- a ]isoquinoline derivatives… Click to show full abstract
Abstract A K 3 PO 4 promoted dipolar [3+3] cyclization of dihydroisoquinoline imines and arylacyl bromides has been developed. This process realized the direct synthesis of pyrazino[2,1- a ]isoquinoline derivatives in 44–69% yields. A head to tail dimerization was proposed as key step for this procedure.
Keywords:
dipolar cyclization;
direct synthesis;
synthesis pyrazino;
isoquinoline derivatives;
pyrazino isoquinoline;
promoted dipolar
Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
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recommendations!