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Abstract In this study we developed a novel copper-catalyzed O–H insertion of tetraethyl diphosphonodiazomethane into carboxylic acids, providing a simple method to link bisphosphonates to compounds containing carboxyl group. Moreover,… Click to show full abstract
Abstract In this study we developed a novel copper-catalyzed O–H insertion of tetraethyl diphosphonodiazomethane into carboxylic acids, providing a simple method to link bisphosphonates to compounds containing carboxyl group. Moreover, a novel bone-targeting prodrug of naproxen was synthesized according to this new methodology, and the preliminary evaluation indicated that the prodrug exhibited excellent bone affinity in vitro .
Keywords:
moiety inserting;
inserting bond;
carboxylic acids;
effective method;
method bisphosphonate;
bisphosphonate moiety
Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
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recommendations!