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Abstract A Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles with o-vinylphenols as an efficient approach to alkenyl-substituted aminocyclopentenes is reported. This protocol represents another classic example for direct C–H activation of terminal… Click to show full abstract
Abstract A Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles with o-vinylphenols as an efficient approach to alkenyl-substituted aminocyclopentenes is reported. This protocol represents another classic example for direct C–H activation of terminal alkenes using enol as directing group. The reaction features the ease of the preparation of starting materials, fast and high efficiency, broad substrate scope and 100% atom economy, thus provides a valuable entry to synthesize novel substituted cyclopentenes.
Journal Title: Tetrahedron Letters
Year Published: 2018
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