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Novel synthesis of aminoacetonitriles via the selective demethylation of quaternary ammonium salts

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Abstract N -Methyl cyclic amines readily formed quaternary ammonium salts upon treatment with iodoacetonitrile in high yields (70–96%). The latter were selectively demethylated by heating in dimethylformamide to give aminoacetonitriles… Click to show full abstract

Abstract N -Methyl cyclic amines readily formed quaternary ammonium salts upon treatment with iodoacetonitrile in high yields (70–96%). The latter were selectively demethylated by heating in dimethylformamide to give aminoacetonitriles in moderate to good overall yields (36–69%).

Keywords: ammonium salts; aminoacetonitriles via; novel synthesis; quaternary ammonium; synthesis aminoacetonitriles

Journal Title: Tetrahedron Letters
Year Published: 2018

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