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Selective cleavage of the N-propargyl group from sulfonamides and amides under ruthenium catalysis

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Abstract The selective cleavage of the N-propargyl group from sulfonamides and amides under ruthenium catalysis is described. The reaction tolerates a broad range of functional groups, and the desired products… Click to show full abstract

Abstract The selective cleavage of the N-propargyl group from sulfonamides and amides under ruthenium catalysis is described. The reaction tolerates a broad range of functional groups, and the desired products were obtained in 10–95% yield.

Keywords: cleavage propargyl; group sulfonamides; propargyl group; sulfonamides amides; amides ruthenium; selective cleavage

Journal Title: Tetrahedron Letters
Year Published: 2018

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