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PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes

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Abstract A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free… Click to show full abstract

Abstract A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free atmosphere and has also been scaled up to grams making it suitable for commercialization. The reactions also have been successfully carried out with asymmetric variants, thus contributing to the chiral pool. The user friendly “trio” enables easy generation of these versatile sulfur analogues and the reaction condition employed depict an economic outline.

Keywords: mediated open; air synthesis; open air; ptab mediated; sulfonamides thiosulfonates

Journal Title: Tetrahedron Letters
Year Published: 2018

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