Photo by jakobowens1 from unsplash
Abstract An efficient “one-pot” method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition… Click to show full abstract
Abstract An efficient “one-pot” method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of acrylate derivatives on treatment with NaN 3 in DMF under mild conditions.
Keywords:
azidation intramolecular;
tandem azidation;
cycloaddition aromatization;
acrylate derivatives;
intramolecular cycloaddition;
synthesis
Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!