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Abstract Chiral imidodiphosphoric acids were employed as catalysts for the enantioselective α-chlorination of β-keto esters and amides using NCS as the chlorine source, providing a series of optically active products… Click to show full abstract
Abstract Chiral imidodiphosphoric acids were employed as catalysts for the enantioselective α-chlorination of β-keto esters and amides using NCS as the chlorine source, providing a series of optically active products with good to high enantioselectivities (74–95% ee) and excellent yields (92–99%). This represents the first report of the Bronsted acid catalyzed enantioselective α-chlorination of cyclic β-keto derivatives.
Keywords:
chiral imidodiphosphoric;
chlorination;
chlorination keto;
enantioselective chlorination;
imidodiphosphoric acids
Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
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recommendations!