Abstract A new cytotoxic polycyclic alkaloid containing a quinoline moiety, njaoamine I ( 1 ) has been isolated from the methanol extract of the sponge Haliclona ( Reniera ) sp.… Click to show full abstract
Abstract A new cytotoxic polycyclic alkaloid containing a quinoline moiety, njaoamine I ( 1 ) has been isolated from the methanol extract of the sponge Haliclona ( Reniera ) sp. collected at Okuza Island, Tanzania. The structure of compound 1 was determined by 1D and 2D NMR and HRMS data analysis. Its relative configuration was elucidated by a NOESY experiment and confirmed by comparison of its NMR spectral data to those of njaoamines A–H. Moreover, njaoamine G ( 2 ) was also detected by LC/MS analysis of the methanol extract. Njaoamine I ( 1 ) displays cytotoxic activity against a panel of three human tumor cell lines in the micromolar range.
Journal Title: Tetrahedron Letters
Year Published: 2018
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