Abstract The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating… Click to show full abstract
Abstract The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating agents and, unlike the traditional Castagnoli-Cushman reaction of homophthalic anhydride, allows simultaneous mixing of all three reagents and provides good to excellent yields of trans-configured tetrahydroisoquinolonic acids.
Keywords:
castagnoli cushman;
three component;
component format;
cushman reaction
Journal Title: Tetrahedron Letters
Year Published: 2018
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Journal Title: Tetrahedron Letters
Year Published: 2018
Link to full text (if available)
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recommendations!