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Efficient sulfonylation of ketones with sodium sulfinates for the synthesis of β-keto sulfones

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Abstract The oxidative sulfonylation of ketones with sodium sulfinates as the sulfone source and DMSO as the oxidant is reported. A series of β-keto sulfones were obtained in good to… Click to show full abstract

Abstract The oxidative sulfonylation of ketones with sodium sulfinates as the sulfone source and DMSO as the oxidant is reported. A series of β-keto sulfones were obtained in good to excellent yields. The advantages of this efficient protocol include the low cost of DMSO and HBr, and a broad scope.

Keywords: sodium sulfinates; sulfonylation ketones; ketones sodium; keto sulfones

Journal Title: Tetrahedron Letters
Year Published: 2018

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