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Facile and practical synthesis of π-extended oxepins by benzannulation and intramolecular cyclization

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Abstract π-Extended oxepins 1 and dimer 8 were synthesized by the benzannulation of the corresponding asymmetric diarylacetylene derivatives and 2-(phenylethynyl)benzaldehyde followed by the Cu-catalyzed intramolecular cyclization. The optical properties of… Click to show full abstract

Abstract π-Extended oxepins 1 and dimer 8 were synthesized by the benzannulation of the corresponding asymmetric diarylacetylene derivatives and 2-(phenylethynyl)benzaldehyde followed by the Cu-catalyzed intramolecular cyclization. The optical properties of the π-extended oxepins 1 and 8 are also investigated.

Keywords: intramolecular cyclization; extended oxepins; benzannulation; facile practical; practical synthesis

Journal Title: Tetrahedron Letters
Year Published: 2019

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