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Abstract The stereoselective allylation of acyclic chiral α-amino aldimines affording vicinal diamines, mediated by various Lewis acids (TiCl4, SnCl4, MgBr2·OEt2, BF3·OEt2, ZnCl2), is described. The TiCl4-mediated allylation of an α-N-Boc… Click to show full abstract
Abstract The stereoselective allylation of acyclic chiral α-amino aldimines affording vicinal diamines, mediated by various Lewis acids (TiCl4, SnCl4, MgBr2·OEt2, BF3·OEt2, ZnCl2), is described. The TiCl4-mediated allylation of an α-N-Boc aldimine afforded the allylation product with syn-selectivity, which in turn was used for the synthesis of an intermediate of an oseltamivir derivative.
Keywords:
allylation acyclic;
amino aldimines;
allylation;
stereoselective allylation;
chiral amino;
acyclic chiral
Journal Title: Tetrahedron Letters
Year Published: 2019
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Journal Title: Tetrahedron Letters
Year Published: 2019
Link to full text (if available)
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recommendations!