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Abstract The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide… Click to show full abstract
Abstract The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)2.
Keywords:
catalyzed microwave;
substituted methyloxazoles;
otf catalyzed;
propargylic amides;
microwave promoted;
promoted synthesis
Journal Title: Tetrahedron Letters
Year Published: 2019
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Journal Title: Tetrahedron Letters
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!