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Abstract An unprecedented NH4I-promoted N-formylation and N-acetylization of various amines with dimethylformamide (DMF) and dimethylacetamide (DMA) has been developed. This protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic… Click to show full abstract
Abstract An unprecedented NH4I-promoted N-formylation and N-acetylization of various amines with dimethylformamide (DMF) and dimethylacetamide (DMA) has been developed. This protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic amines, which provides a metal-free strategy for N-acylation featuring mild reaction conditions, as well as inexpensive and readily available starting materials.
Keywords:
promoted acylation;
acylation amines;
nh4i promoted;
metal free;
dma
Journal Title: Tetrahedron Letters
Year Published: 2019
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!