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Peroxide-mediated oxidative coupling of primary alcohols and disulfides: Synthesis of 2-substituted benzothiazoles

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Abstract A peroxide-mediated protocol for the synthesis of 2-substituted benzothiazoles was developed, starting from bis( o -aminophenyl) disulfides and primary alcohols. Eleven differently 2-substituted benzothiazoles were prepared in moderate to… Click to show full abstract

Abstract A peroxide-mediated protocol for the synthesis of 2-substituted benzothiazoles was developed, starting from bis( o -aminophenyl) disulfides and primary alcohols. Eleven differently 2-substituted benzothiazoles were prepared in moderate to excellent yields using di- tert -butyl peroxide (DTBP) as an oxidant.

Keywords: synthesis substituted; primary alcohols; substituted benzothiazoles; mediated oxidative; peroxide mediated

Journal Title: Tetrahedron Letters
Year Published: 2019

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