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Chiral tetraoxacalix[2]arene[2]triazine-based organocatalysts for Enantioselective Aldol reactions

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Abstract Novel efficient chiral tetraoxacalix[2]arene[2]triazine-based organocatalysts have been designed and synthesized from the reaction of tetraoxacalix[2]arene[2]triazine with R/S-phenylethylamine or R/S-1-naphthylethylamine for the Aldol reaction of acetone with aromatic aldehydes to… Click to show full abstract

Abstract Novel efficient chiral tetraoxacalix[2]arene[2]triazine-based organocatalysts have been designed and synthesized from the reaction of tetraoxacalix[2]arene[2]triazine with R/S-phenylethylamine or R/S-1-naphthylethylamine for the Aldol reaction of acetone with aromatic aldehydes to furnish the Aldol adducts in 71–92% yields with excellent enantioselectivities (78–99%).

Keywords: tetraoxacalix arene; triazine based; based organocatalysts; chiral tetraoxacalix; arene triazine

Journal Title: Tetrahedron Letters
Year Published: 2019

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