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Abstract Three new inositol derivatives ( 1 – 3 ) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam, along with four known compounds, including a limonoid (… Click to show full abstract
Abstract Three new inositol derivatives ( 1 – 3 ) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam, along with four known compounds, including a limonoid ( 4 ), two triterpenoids ( 5 – 6 ), and a tocopherol ( 7 ). The structures of the new compounds were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 4 showed the highest cytotoxicities against the human lung cancer A549 and cervical cancer HeLa cell lines, with IC 50 values of 7.3 and 8.8 µM, respectively, among the isolated compounds. Compounds 5 and 7 displayed moderate to weak cytotoxicities against the A549, HeLa, and human stomach cancer GSU cell lines, with IC 50 values ranging from 17.7 to 68.0 µM.
Journal Title: Tetrahedron Letters
Year Published: 2019
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