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Abstract Two novel epimers, named nuciferols A (1) and B (2), possessing a unique 6.9′, 9.6′, 7′.8″-cyclosesquineolignan skeleton, were isolated from the ethyl acetate fraction of the endocarp of Cocos… Click to show full abstract
Abstract Two novel epimers, named nuciferols A (1) and B (2), possessing a unique 6.9′, 9.6′, 7′.8″-cyclosesquineolignan skeleton, were isolated from the ethyl acetate fraction of the endocarp of Cocos nucifera. Their planar structure was elucidated by 1D-, 2D-NMR, HRESIMS and their absolute configuration was determined by ECD. Nuciferols A and B showed radical scavenging activity using DPPH assay, and only nuciferol B showed neuroprotective effects against t-BHP induced cell death in N2a cells.
Keywords:
nuciferols novel;
sesquineolignans cocos;
novel sesquineolignans;
nucifera;
cocos nucifera
Journal Title: Tetrahedron Letters
Year Published: 2019
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Journal Title: Tetrahedron Letters
Year Published: 2019
Link to full text (if available)
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recommendations!