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Abstract An alternative green protocol and step economy for the synthesis of quinazoline has been developed. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to ortho-aminoaryl N… Click to show full abstract
Abstract An alternative green protocol and step economy for the synthesis of quinazoline has been developed. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to ortho-aminoaryl N H ketimine species. The subsequent base catalysed N C bond formation with various isothiocyanates afforded quinazoline scaffolds in aqueous medium. The salient features of this protocol are use of readily available inexpensive precursors, water as a green environmentally benign solvent, short reaction time, operational simplicity, easy workup procedure and good functional group tolerance.
Journal Title: Tetrahedron Letters
Year Published: 2019
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