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Efficient synthesis of dibenzazepine lactams via a sequential Pd-catalyzed amination and aldol condensation reaction

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Abstract A simple and efficient reaction was developed for the synthesis of dibenzazepine lactam derivatives. The core 7-membered azepine ring was formed by a stepwise sequence involving a palladium-catalyzed amination… Click to show full abstract

Abstract A simple and efficient reaction was developed for the synthesis of dibenzazepine lactam derivatives. The core 7-membered azepine ring was formed by a stepwise sequence involving a palladium-catalyzed amination and an aldol condensation.

Keywords: synthesis dibenzazepine; amination aldol; reaction; catalyzed amination; aldol condensation

Journal Title: Tetrahedron Letters
Year Published: 2020

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