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Abstract A variety of isoxazolo[2,3-c]quinazolines were synthesized via a [3 + 2] cycloaddition of quinazoline-3-oxides with acrylates. The reaction exhibits a broad substrate scope and good functional group tolerance. The corresponding isoxazolo[2,3-c]quinazolines… Click to show full abstract
Abstract A variety of isoxazolo[2,3-c]quinazolines were synthesized via a [3 + 2] cycloaddition of quinazoline-3-oxides with acrylates. The reaction exhibits a broad substrate scope and good functional group tolerance. The corresponding isoxazolo[2,3-c]quinazolines can be obtained in good to excellent yields in 1,4-dioxane.
Keywords:
oxides acrylates;
quinazoline oxides;
cycloaddition quinazoline;
via cycloaddition;
isoxazolo quinazolines
Journal Title: Tetrahedron Letters
Year Published: 2020
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Journal Title: Tetrahedron Letters
Year Published: 2020
Link to full text (if available)
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recommendations!