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A novel synthetic method of 2,4-disubstituted oxazoles using carboxylic acid-derived Bu2Sn[OC(O)R]2

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Abstract A novel synthetic method for the preparation of 2,4-disubstituted oxazoles was developed, entailing the reaction of dibutyltin diacylates Bu2Sn[OC(O)R]2 with 1-substituted acetylenes and TMSN3 to afford a range of… Click to show full abstract

Abstract A novel synthetic method for the preparation of 2,4-disubstituted oxazoles was developed, entailing the reaction of dibutyltin diacylates Bu2Sn[OC(O)R]2 with 1-substituted acetylenes and TMSN3 to afford a range of 2,4-disubstituted oxazoles in good yields.

Keywords: disubstituted oxazoles; novel synthetic; oxazoles using; method disubstituted; synthetic method

Journal Title: Tetrahedron Letters
Year Published: 2020

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