Photo by miguelherc96 from unsplash
Abstract A tandem cyclization reaction of diethyl 2-(2-aminobenzamido)malonates and 2-bromobenzaldehydes was developed for the synthesis of isoindolo[1,2-b]quinazoline derivatives. The quinazoline was formed first catalyzed by CuI, followed by a noteworthy… Click to show full abstract
Abstract A tandem cyclization reaction of diethyl 2-(2-aminobenzamido)malonates and 2-bromobenzaldehydes was developed for the synthesis of isoindolo[1,2-b]quinazoline derivatives. The quinazoline was formed first catalyzed by CuI, followed by a noteworthy α-arylation reaction under Pd and ligand-free conditions in the presence of Cs2CO3.
Keywords:
free conditions;
ligand free;
isoindolo quinazoline;
quinazoline derivatives;
synthesis isoindolo
Journal Title: Tetrahedron Letters
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Tetrahedron Letters
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!