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Abstract The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using… Click to show full abstract
Abstract The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using a linear seven-step sequence. The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti-hyphal formation test. Childnin E and two derivatives exhibited anti-hyphal formation activity.
Keywords:
several derivatives;
hyphal formation;
anti hyphal;
candida albicans;
childinin several
Journal Title: Tetrahedron Letters
Year Published: 2020
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!