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Abstract An efficient telescope method for the preparation of furan-2(5H)-one derivatives containing 4H-chromen-4-one fragment was developed. The suggested approach based on tandem multicomponent reaction of 3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one, arylglyoxals and Meldrum’s acid.… Click to show full abstract
Abstract An efficient telescope method for the preparation of furan-2(5H)-one derivatives containing 4H-chromen-4-one fragment was developed. The suggested approach based on tandem multicomponent reaction of 3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one, arylglyoxals and Meldrum’s acid. A distinctive feature of the proposed protocol is simultaneous formation of 4H-chromen-4-one and furan-2(5H)-one fragments at one synthetic stage. The advantages of this synthesis are mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structure of one of furan-2(5H)-one derivatives was determined by X-ray diffraction.
Journal Title: Tetrahedron Letters
Year Published: 2020
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