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Abstract A concise synthetic approach to construct [6] , [6] , [6] -tricyclic core, bearing 14-membered carbocyclic skeleton and oxygen at C13 of lophotoxin, has been described. This approach features… Click to show full abstract
Abstract A concise synthetic approach to construct [6] , [6] , [6] -tricyclic core, bearing 14-membered carbocyclic skeleton and oxygen at C13 of lophotoxin, has been described. This approach features a diastereoselective intermolecular Diels−Alder furan reaction and intramolecular Michael reaction. N-methylmaleimide was found to be critical for achieving the stable intermolecular Diels−Alder furan outcome.
Keywords:
lophotoxin;
model study;
synthesis lophotoxin;
total synthesis;
study total
Journal Title: Tetrahedron Letters
Year Published: 2021
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2021
Link to full text (if available)
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recommendations!