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Lindquist was a visionary and pioneer who transformed our understanding of how protein folding sculpts biology, evolution, and disease. She revealed several unanticipated mechanisms by which protein folding can buffer,… Click to show full abstract
Lindquist was a visionary and pioneer who transformed our understanding of how protein folding sculpts biology, evolution, and disease. She revealed several unanticipated mechanisms by which protein folding can buffer, release, and potentiate genetic variation in response to environmental stress, thereby enabling the rapid evolution of beneficial new traits. Her discoveries provide a rich framework for innovative therapeutic interventions in several fatal diseases, including Alzheimer's disease, Parkinson's disease, and cancer.
Journal Title: Trends in Biochemical Sciences
Year Published: 2017
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