LAUSR

Much work over the past three decades has established that chemical modifications of DNA and histones are intimately linked with various facets of DNA metabolism, most notably transcription. In addition to chromatin components, RNA has long been known to be chemically modified [1]. The N6-methyladenosine (m6A) RNA modification has recently emerged as a widely prevalent RNA mark [2]. First discovered in the 1970s, m6A is found in many eukaryotes, as well as in some viruses, and is a feature of many RNA species, including mRNAs, tRNAs, rRNAs, snRNAs, and lncRNAs [1,2].