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Protein engineering advances, including DNA repair manipulation of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) machinery, have paved the way for the first set of DNA precision base editors (C•G→T•A… Click to show full abstract
Protein engineering advances, including DNA repair manipulation of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) machinery, have paved the way for the first set of DNA precision base editors (C•G→T•A and A•T→G•C), with wide-ranging implications for treating many human genetic diseases. By utilizing the latest protein evolution advances, a hypothetical model for the first transversion (C•G→G•C) base editor can now be proposed.
Keywords:
designing elusive;
base;
elusive crispr;
base editor
Journal Title: Trends in biochemical sciences
Year Published: 2019
Link to full text (if available)
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Journal Title: Trends in biochemical sciences
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!