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The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR)… Click to show full abstract
The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to inactivate the production of abundant antibiotics generates a metabolic clean slate for the detection and/or isolation of new and less plentiful antibiotics activated in mutant strains.
Keywords:
unearthing hidden;
chemical potential;
actinobacterial libraries;
discarded actinobacterial;
potential discarded;
hidden chemical
Journal Title: Trends in biotechnology
Year Published: 2019
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Journal Title: Trends in biotechnology
Year Published: 2019
Link to full text (if available)
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recommendations!