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Engineering polyketide biosynthesis to enable the production of diverse chemical structures is a major challenge at present. Utilising an established biosynthetic cassette for terminal alkyne production, Porterfield et al. applied… Click to show full abstract
Engineering polyketide biosynthesis to enable the production of diverse chemical structures is a major challenge at present. Utilising an established biosynthetic cassette for terminal alkyne production, Porterfield et al. applied docking domain and site-directed mutagenesis approaches to interface these enzymes with modular polyketide synthase (PKS) enzymes, yielding products with a bio-orthogonal handle.
Keywords:
clicking place;
polyketide;
biosynthesis;
place interfacing;
terminal alkyne;
interfacing terminal
Journal Title: Trends in biotechnology
Year Published: 2020
Link to full text (if available)
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Journal Title: Trends in biotechnology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!