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Due to low carboxylase activity, CO2 biotransformation is challenging to achieve using natural CO2 fixation pathways. Liu et al. have improved the activity of propionyl-CoA carboxylase (PCC) 94-fold, enabling the… Click to show full abstract
Due to low carboxylase activity, CO2 biotransformation is challenging to achieve using natural CO2 fixation pathways. Liu et al. have improved the activity of propionyl-CoA carboxylase (PCC) 94-fold, enabling the efficient synthesis of succinate from acetyl-CoA and paving the way for CO2 assimilation via the 3-hydroxypropionate (3-HP) bicycle or 3-hydroxypropionate/4-hydroxybutyrate (3-HP/4-HB) cycle.
Keywords:
carboxylase;
propionyl coa;
coa;
directed evolution;
coa carboxylase
Journal Title: Trends in biotechnology
Year Published: 2021
Link to full text (if available)
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Journal Title: Trends in biotechnology
Year Published: 2021
Link to full text (if available)
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recommendations!