LAUSR

In a recent article, Quiroga argued that pattern separation may not occur in the human hippocampus [1]. This argument was based on neuronal recordings in the human hippocampus that showed that many neurons respond to overlapping representations and thus may not reflect pattern separation. However, it is important to assess why pattern separation is especially important in specific parts of the hippocampus such as the dentate gyrus and CA3 (Figure 1), and to assess the type of investigation needed to support the claim that pattern separation does not occur in the human hippocampus, by comparing the currently available findings in humans with those in other primates.