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The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a 'case study' to… Click to show full abstract
The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a 'case study' to contrast the genetic landscape in natural populations with standard infection models, discussing new strategies to bridge this gap.
Keywords:
laboratory strains;
strains limit;
diversity homogeneous;
limit discovery;
homogeneous laboratory;
modeling diversity
Journal Title: Trends in microbiology
Year Published: 2018
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Journal Title: Trends in microbiology
Year Published: 2018
Link to full text (if available)
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recommendations!