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A Self-Killing Rabies Virus That Leaves a Trace on the DNA

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Although modified rabies viruses have emerged as a powerful tool for tracing the inputs to genetically defined populations of neurons, the toxicity of the virus has limited its utility. A… Click to show full abstract

Although modified rabies viruses have emerged as a powerful tool for tracing the inputs to genetically defined populations of neurons, the toxicity of the virus has limited its utility. A recent study employed a self-inactivating rabies (SiR) virus that enables recording or manipulation of targeted neurons for months.

Keywords: rabies virus; self killing; trace dna; killing rabies; leaves trace; virus leaves

Journal Title: Trends in Neurosciences
Year Published: 2017

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