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Microbes and Alzheimer’s Disease: New Findings Call for a Paradigm Change

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Two papers in Neuron provide compelling new indications of a link between herpesviruses and Alzheimer's disease (AD). Readhead et al. report an increased abundance of human herpesviruses 6A and 7… Click to show full abstract

Two papers in Neuron provide compelling new indications of a link between herpesviruses and Alzheimer's disease (AD). Readhead et al. report an increased abundance of human herpesviruses 6A and 7 (HHV-6A/7) in AD brain, whereas Eimer et al. show that binding of the AD signature protein, Aβ, to herpes simplex virus type 1 (HSV-1) and HHV-6 surface glycoproteins causes fibrillar Aβ agglutination that can protect against viral challenge.

Keywords: disease new; microbes alzheimer; alzheimer disease; new findings; findings call; call paradigm

Journal Title: Trends in Neurosciences
Year Published: 2018

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