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In a recent study, Tracy et al. observed that Tau interacts with mitochondrial and presynaptic vesicle proteins in human iPSC-derived neurons. Tau with mutations that cause neurodegeneration has decreased mitochondrial… Click to show full abstract
In a recent study, Tracy et al. observed that Tau interacts with mitochondrial and presynaptic vesicle proteins in human iPSC-derived neurons. Tau with mutations that cause neurodegeneration has decreased mitochondrial interactions. This elegant interactome mapping with supporting human brain data paves the way to a better understanding of Tau pathology and future Tau-directed therapeutics.
Keywords:
tau talk;
talk synaptic;
mitochondrial proteins;
proteins interact;
synaptic mitochondrial;
neurons tau
Journal Title: Trends in neurosciences
Year Published: 2022
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Journal Title: Trends in neurosciences
Year Published: 2022
Link to full text (if available)
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recommendations!