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Recently, Perrin et al. reported the application of thermal proteome profiling (TPP), a cellular thermal shift assay with an unbiased proteomics readout to complex tissue samples from model organisms and… Click to show full abstract
Recently, Perrin et al. reported the application of thermal proteome profiling (TPP), a cellular thermal shift assay with an unbiased proteomics readout to complex tissue samples from model organisms and patient-derived whole blood. This study demonstrates for the first time that TPP enables organ-specific drug target engagement and identification studies during the later stages of drug discovery and even in a clinical setting.
Keywords:
characterizing drug;
drug;
drug target;
interactions shifting;
target interactions
Journal Title: Trends in pharmacological sciences
Year Published: 2020
Link to full text (if available)
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Journal Title: Trends in pharmacological sciences
Year Published: 2020
Link to full text (if available)
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recommendations!