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Technologies stabilizing the active state of G protein-coupled receptors (GPCRs) represent potential breakthroughs for interrogating G protein activation. Camelid nanobodies have been used as a 'one tool, one receptor' paradigm.… Click to show full abstract
Technologies stabilizing the active state of G protein-coupled receptors (GPCRs) represent potential breakthroughs for interrogating G protein activation. Camelid nanobodies have been used as a 'one tool, one receptor' paradigm. However, the development of G protein peptidomimetics, as discussed in Mannes et al. represent the opportunity to develop generically activating probes for many GPCRs.
Keywords:
peptidomimetics stabilize;
protein peptidomimetics;
active state;
gpcr active;
stabilize gpcr
Journal Title: Trends in pharmacological sciences
Year Published: 2021
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Journal Title: Trends in pharmacological sciences
Year Published: 2021
Link to full text (if available)
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recommendations!