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Single-channel analysis previously revealed a key role for a short-lived 'flipped' state during glycine receptor activation by partial agonists. Structures solved by Yu and colleagues now reveal a surprising mechanism… Click to show full abstract
Single-channel analysis previously revealed a key role for a short-lived 'flipped' state during glycine receptor activation by partial agonists. Structures solved by Yu and colleagues now reveal a surprising mechanism involving a partially activated agonist-bound closed state that is too long-lived to be considered the flipped state.
Keywords:
state;
partial agonists;
agonists molecular
Journal Title: Trends in pharmacological sciences
Year Published: 2021
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Journal Title: Trends in pharmacological sciences
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!