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An alternative approach to organising this knowledge is the use of adverse outcome pathways (AOPs). An AOP is a mechanistic representation linking a molecular initiating event (MIE) to an adverse… Click to show full abstract
An alternative approach to organising this knowledge is the use of adverse outcome pathways (AOPs). An AOP is a mechanistic representation linking a molecular initiating event (MIE) to an adverse outcome (AO) through sequential key events (KEs). KEs are described at a defined level of biological organisation and linked together according to known biological mechanisms which are supported by empirical evidence.
Keywords:
adverse outcome;
outcome;
framework carcinogenicity;
outcome pathway;
developing adverse;
pathway framework
Journal Title: Toxicology Letters
Year Published: 2018
Link to full text (if available)
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Journal Title: Toxicology Letters
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!