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Highlights • Oxidative Stress is the key mechanism involved in Lead, Mercury, Cadmium and Arsenic-induced kidney toxicity.• Proteinuria is common to all heavy metals as manifestation of kidney damage.• Chelation… Click to show full abstract
Highlights • Oxidative Stress is the key mechanism involved in Lead, Mercury, Cadmium and Arsenic-induced kidney toxicity.• Proteinuria is common to all heavy metals as manifestation of kidney damage.• Chelation therapy is recommended based on the dose size of heavy metals, though fatal drawbacks limit their success.• Possible effectiveness of plants and plants derived compound against heavy metals is due to their antioxidant activity.• Other possible effectiveness of plant includes protecting integrity of mitochondria, Ca2+ homeostasis and apoptosis regulation.
Journal Title: Toxicology Reports
Year Published: 2018
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