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Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line

Highlights • We evaluated glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione.• Gene expression alterations were measured in the HepaRG liver cell line.• Quizalofop-p-ethyl was the most toxic, causing alterations in lipid metabolism.•… Click to show full abstract

Highlights • We evaluated glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione.• Gene expression alterations were measured in the HepaRG liver cell line.• Quizalofop-p-ethyl was the most toxic, causing alterations in lipid metabolism.• Isoxaflutole was less toxic, but was revealed as a possible PXR activator.• Glyphosate and mesotrione only caused subtle changes in transcriptome profiles.

Keywords: quizalofop; mesotrione; isoxaflutole quizalofop; glyphosate isoxaflutole; quizalofop ethyl

Journal Title: Toxicology Reports
Year Published: 2018

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